TRIFLUOROACETIC ACID AMIDE
2,2,2-Trifluoroacetamide
CAS: 354-38-1
Molecular Formula: C2H2F3NO
TRIFLUOROACETIC ACID AMIDE - Names and Identifiers
| Name | 2,2,2-Trifluoroacetamide |
| Synonyms | CF3CONH2 Triflouroacetamide TRIFLUOROACETAMIDE Trifluoroacetamide Three fluoroacetaMide 2,2,2-TRIFLUOROACETAMIDE 2,2,2-Trifluoro-Acetamid 2,2,2-trifluoro-acetamid 2,2,2-trifluoroacetanide 2,2,2-Trifluoroacetamide 2,2,2-Trifluroracetaminde Trifluoroacetic Acid Amide TRIFLUOROACETIC ACID AMIDE Acetamide, 2,2,2-Trifluoro- bis(pentafluoroethyl)phosphinous chloride |
| CAS | 354-38-1 |
| EINECS | 206-559-9 |
| InChI | InChI=1/C4ClF10P/c5-16(3(12,13)1(6,7)8)4(14,15)2(9,10)11 |
| InChIKey | NRKYWOKHZRQRJR-UHFFFAOYSA-N |
TRIFLUOROACETIC ACID AMIDE - Physico-chemical Properties
| Molecular Formula | C2H2F3NO |
| Molar Mass | 113.04 |
| Density | 1.4176 (estimate) |
| Melting Point | 65-70 °C (lit.) |
| Boling Point | 162.5 °C (lit.) |
| Flash Point | 162-164°C |
| Water Solubility | 460 g/L (20 ºC) |
| Solubility | 460 g/L (20°C) |
| Vapor Presure | 139mmHg at 25°C |
| Appearance | White to light brown crystals or powders |
| Color | White to pale yellow or beige |
| BRN | 1753625 |
| pKa | 12.33±0.50(Predicted) |
| PH | 3.6 (460g/l, H2O, 23℃) |
| Storage Condition | Store below +30°C. |
| Sensitive | Sensitive to light |
| MDL | MFCD00008008 |
| Physical and Chemical Properties |
|
| Use | Organic synthesis. Synthesis of primary amines from halides or methanesulfonic acid compounds. |
TRIFLUOROACETIC ACID AMIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | 1759 |
| WGK Germany | 3 |
| TSCA | T |
| HS Code | 29241900 |
| Hazard Note | Harmful/Irritant |
| Hazard Class | 8 |
| Packing Group | III |
TRIFLUOROACETIC ACID AMIDE - Reference
| Reference Show more | 1. Li Geng, Zhao genu, Liu Zi Yu, Zhao genu, Wang Miao, Zhao Chunjie, Xu Haiyan. Determination of isotopic abundance of ~(13)C-labeled amino acids and metabolites in HepG2 cells [J]. Journal of Shenyang Pharmaceutical University, 2020,37(11):990-997. |
TRIFLUOROACETIC ACID AMIDE - Introduction
Soluble in water. Toxic. It's irritating.
Last Update：2022-10-16 17:24:50
TRIFLUOROACETIC ACID AMIDE - Reference Information
| LogP | 0.725 at 23℃ and pH4.83 |
| dissociation constant | 0 at 23 ℃ |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Overview | Trifluoroacetamide is an important organic chemical raw material, mainly used to synthesize trifluoroacetonitrile and 2-trifluoromethyl-4-ethoxycarbonyl-1, 3-thiazole and other organic fluorine compounds, can also be used to prepare pesticides, medicines, and industrial chemicals. |
| preparation | ethyl trifluoroacetate is put into an acylation kettle with a pump, ammonia gas is introduced under stirring, and the reaction of ammonia gas is normal pressure, temperature 30 ℃, and reaction for 8 hours. The intermediate trifluoroacetamide is obtained by concentration, crystallization and centrifugation. |
| application | trifluoroacetamide can be used to prepare N,O-bis-trimethylsilyl trifluoroacetamide. N,O-bis-trimethylsilyl trifluoroacetamide is an important pharmaceutical intermediate. It is mainly used as a neutral silanization reagent in the silanization protection of amino groups, amino acids, phenols, carboxylic acids and enols. As a mild neutral silanization reagent, it not only has high reaction activity and good selectivity, but also has the advantages of high reaction yield and simple post-treatment. |
| use | organic synthesis. Synthesis of primary amines from halides or methanesulfonic acid compounds. |
Last Update：2024-04-09 21:04:16
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